Saturday, January 14, 2006

Wine polyphenols and vascular disease

The proliferation of vascular smooth muscle cells is seen in the initiation and development of atherosclerosis.

In France, despite a high intake of dietary cholesterol and saturated fat, the cardiovascular death rate is one of the lowest among developed countries. This "French paradox" has been postulated to be related to the high red wine intake in France.

In vitro results now suggest that resveratrol, a major polyphenol component of red wine, inhibits, in a dose-dependent manner, smooth muscle cell proliferation, which may help to partially explain a beneficial effect of wine drinking and the "French Paradox." The study supports the conjecture that red wine consumption may have a beneficial effect on cardiovascular mortality.

Consider New York wines for their resveratrol content. An analysis of wines showed that the average resveratrol content of all New York wines tested was 7.5 µM, compared with 5.8 µM for non-New York reds and 5 µM for California red wines

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